The switch region associated with immunoglobulin Cμ genes is DNase I hypersensitive in T lymphocytes

@article{Storb1981TheSR,
  title={The switch region associated with immunoglobulin Cμ genes is DNase I hypersensitive in T lymphocytes},
  author={Ursula Storb and Benjamin Arp and Ronald Wilson},
  journal={Nature},
  year={1981},
  volume={294},
  pages={90-92}
}
It is not known whether the antigen-specific receptor of T lymphocytes is encoded by conventional immunoglobulin genes. Several T-cell lines, as well as thymus cells, have been found to contain aberrant IgM mRNAs, but other T-cell lines are apparently negative1–4. Rearrangement of D and J gene segments which code for portions of immunoglobulin heavy (H) chain variable (V) regions has been observed in some T cells, but no complete V–D–J rearrangements, as required for H gene expression in B… CONTINUE READING

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