The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function.

@article{Singh2010TheSO,
  title={The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function.},
  author={Anurag K. Singh and Brigitte Riederer and Mingmin Chen and Fang Xiao and Anja Krabbenh{\"o}ft and Regina Engelhardt and Olof Nylander and Manoocher Soleimani and Ursula Seidler},
  journal={American journal of physiology. Cell physiology},
  year={2010},
  volume={298 5},
  pages={C1057-65}
}
CFTR has been recognized to function as both an anion channel and a key regulator of Slc26 anion transporters in heterologous expression systems. Whether this regulatory relationship between CFTR and Slc26 transporters is seen in native intestine, and whether this effect is coupled to CFTR transport function or other features of this protein, has not been studied. The duodena of anesthetized CFTR-, NHE3-, Slc26a6-, and Scl26a3-deficient mice and wild-type (WT) littermates were perfused, and… CONTINUE READING
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