The switch from latent to productive infection in epstein-barr virus-infected B cells is associated with sensitization to NK cell killing.

@article{Pappworth2007TheSF,
  title={The switch from latent to productive infection in epstein-barr virus-infected B cells is associated with sensitization to NK cell killing.},
  author={Isabel Y. Pappworth and Eddie C Y Wang and Martin Rowe},
  journal={Journal of virology},
  year={2007},
  volume={81 2},
  pages={474-82}
}
Following activation of Epstein-Barr virus (EBV)-infected B cells from latent to productive (lytic) infection, there is a concomitant reduction in the level of cell surface major histocompatibility complex (MHC) class I molecules and an impaired antigen-presenting function that may facilitate evasion from EBV-specific CD8+ cytotoxic T cells. In some other herpesviruses studied, most notably human cytomegalovirus (HCMV), evasion of virus-specific CD8+ effector responses via downregulation of… CONTINUE READING

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