The sweet spot: how GAGs help chemokines guide migrating cells.


Glycosaminoglycans are polysaccharides that occur both at the cell surface and within extracellular matrices. Through their ability to bind to a large array of proteins, almost 500 of which have been identified to date, including most chemokines, these molecules regulate key biologic processes at the cell-tissue interface. To do so, glycosaminoglycans can… (More)
DOI: 10.1189/jlb.3MR0915-440R


5 Figures and Tables