The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population.

@article{Guan2008TheST,
  title={The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population.},
  author={Cui-ping Guan and Miao-ni Zhou and Aie Xu and Ke-fei Kang and Ji-feng Liu and Xiao-dong Wei and Yong-wei Li and De-Kuang Zhao and Wei-song Hong},
  journal={Experimental dermatology},
  year={2008},
  volume={17 12},
  pages={1059-62}
}
Vitiligo is an acquired pigmentary disorder and its pathogenesis remains unclear. Oxidative stress is considered to be the initial pathogenic event in the melanocyte destruction. NF-E2-related factor2 (Nrf2) is a transcription factor regulating the expression of detoxifying and antioxidant genes. To investigate the association of the Nrf2 gene promoter polymorphisms with vitiligo in Chinese Han population, the genotypes of -686A/G, -684G/A and -650C/A and the genotyping of variable number of… CONTINUE READING

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