The survival probability of beneficial de novo mutations in budding viruses, with an emphasis on influenza A viral dynamics

Abstract

A deterministic model is developed of the within-host dynamics of a budding virus, and coupled with a detailed life-history model using a branching process approach to follow the fate of de novo beneficial mutations affecting five life-history traits: clearance, attachment, eclipse, budding, and cell death. Although the model can be generalized for any… (More)

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