The survival of motor neurons protein determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy.

@article{Wan2005TheSO,
  title={The survival of motor neurons protein determines the capacity for snRNP assembly: biochemical deficiency in spinal muscular atrophy.},
  author={Lili Wan and Daniel J. Battle and Jeongsik Yong and Amelie K. Gubitz and Stephen J. Kolb and Jin Wang and Gideon Dreyfuss},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 13},
  pages={5543-51}
}
Reduction of the survival of motor neurons (SMN) protein levels causes the motor neuron degenerative disease spinal muscular atrophy, the severity of which correlates with the extent of reduction in SMN. SMN, together with Gemins 2 to 7, forms a complex that functions in the assembly of small nuclear ribonucleoprotein particles (snRNPs). Complete depletion of the SMN complex from cell extracts abolishes snRNP assembly, the formation of heptameric Sm cores on snRNAs. However, what effect, if any… CONTINUE READING

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