The survival of colony-forming units in mouse bone-marrow after in vivo irradiation with D-T neutrons, X- and gamma-radiation.

@article{Broerse1971TheSO,
  title={The survival of colony-forming units in mouse bone-marrow after in vivo irradiation with D-T neutrons, X- and gamma-radiation.},
  author={Johan J. Broerse and A. C. Engels and P. Lelieveld and L. M. van Putten and W Duncan and David Greene and John B. Massey and Colleen J. Gilbert and Jolyon H. Hendry and Alma Howard},
  journal={International journal of radiation biology and related studies in physics, chemistry, and medicine},
  year={1971},
  volume={19 2},
  pages={
          101-10
        }
}
  • J. Broerse, A. C. Engels, +7 authors A. Howard
  • Published 1971
  • Biology, Medicine
  • International journal of radiation biology and related studies in physics, chemistry, and medicine
SummaryIn collaborative experiments the CFU survival in mouse bone-marrow has been investigated after in vivo irradiation with D–T neutrons, 300 kV x-rays and 60Co and 137Cs gamma-rays. All the survival curves for x- and gamma-radiation showed the same extrapolation number (2·47 ± 0·28), whereas D0 values of 72·2 ± 1·7 rads and 90·7 ± 2·4 rads, respectively, were found for the two types of radiation. With D–T neutrons, the Manchester group found a D0 value of 62·5 ± 2·2 rads; the Rijswijk group… Expand
The response of haemopoietic colony-forming units and lymphoma cells irradiated in soft tissue (spleen) or a bone cavity(femur) with single doses of X rays, rays or D-T neutrons.
  • J. Hendry
  • Medicine
  • The British journal of radiology
  • 1972
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A comparison of the effects of radiation on the different cell types used in the present experiments has shown that, in general, single doses of fast neutrons are no worse (in damaging norm... Expand
In vitro studies of the sensitivity of canine bone-marrow erythroid burst-forming units (BFU-E) and fibroblast colony-forming units (CFU-F) to X-irradiation.
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It is demonstrated that a single dose of 2 Gy 6 MeV neutrons causes significant injury in function (PF) and structure (CFU-S numbers, CR) of bone marrow which persisted up to one year. Expand
The r.b.e. of different-energy neutrons as determined by human bone-marrow cell-culture techniques.
  • A. Bøyum, A. Carsten, +4 authors E. Cronkite
  • Chemistry, Medicine
  • International journal of radiation biology and related studies in physics, chemistry, and medicine
  • 1978
The effect of X-rays and different-energy neutrons on human bone-marrow cells was studied using two different cell-culture techniques--diffusion chamber (DC) growth and colony formation in vitroExpand
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With increasing doses of neutrons survival time decreased more rapidly than with x-irradiation so that, in progressing from midlethal to lethal exposures, mean survival time became markedly lower than after equivalent doses of x-rays. Expand
Daily D-T neutron irradiation of mouse intestine.
The intestinal microcolony assay technique, for measuring damage to the progenitor cell population of mouse jejunal epithelium, has been used to demonstrate the following: Single doses of collimatedExpand
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In vitro dose--response curves of unstable chromosome aberrations in human lymphocytes have been obtained for neutron spectra of mean energies 0-7, 0-9, 7-6 and 14-7 MeV, and curves are obtained which are similar in shape to those for conventional cell-survival experiments with comparable neutron Spectra. Expand
The r.b.e. of different energy neutrons as measured by the heamatopoietic spleen-colony technique.
  • A. Carsten, V. Bond, K. Thompson
  • Chemistry, Medicine
  • International journal of radiation biology and related studies in physics, chemistry, and medicine
  • 1976
TLDR
Dose-response curves were obtained for each type of radiation and the Do was determined and the neutron r.b.e. values from the Do compared with 250kVp X-rays were: reactor 1.58, 252Cf 1:59, and accelerator varied from 2.0 Mev to 0.85 at 13.4 MeV. Expand
The dose-dependence of the split-dose response of marrow colony-forming units (CFU-S): similarity to other tissues.
  • J. Hendry
  • Biology, Medicine
  • International journal of radiation biology and related studies in physics, chemistry, and medicine
  • 1979
TLDR
It is concluded that CFU-S cells do not differ markedly, as has been generally believed, from many other cell types in the ability to demonstrate split-dose effects, when the doses used in the experiments are strictly comparable. Expand
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