The survival characteristics of dense sickle cells.

@article{Franco2000TheSC,
  title={The survival characteristics of dense sickle cells.},
  author={Robert S. Franco and Zahida Yasin and Jessica Carlsson Lohmann and Mary B. Palascak and Tam{\'a}s N{\'e}meth and Michael Weiner and Clinton H. Joiner and Donald L. Rucknagel},
  journal={Blood},
  year={2000},
  volume={96 10},
  pages={
          3610-7
        }
}
Sickle red blood cells (RBCs) become depleted of potassium, leading to dehydration and abnormally elevated cellular density. The increased sickling that results is important for both hemolysis and vasocclusion. In this study, sickle cells were subjected to high-speed centrifugation, and the bottom 15% were isolated. This procedure removed light cells and to a variable degree enriched cells that were denser than normal to produce a high-density-enriched (HDE) population of sickle cells… CONTINUE READING

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