The surprising heart: a review of recent progress in cardiac electrophysiology.

@article{Noble1984TheSH,
  title={The surprising heart: a review of recent progress in cardiac electrophysiology.},
  author={Denis Noble},
  journal={The Journal of Physiology},
  year={1984},
  volume={353}
}
  • D. Noble
  • Published 1984
  • Medicine
  • The Journal of Physiology
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The modelling studies reconstructed the physiological mechanisms by which both aging and SCN5A-disruption lead to SND, thereby drawing parallels between these and similar conduction changes in the ventricle that occur in the possibly related condition of PCCD. Expand
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TLDR
The sarcoplasmic reticulum generates spontaneous, but precisely timed, rhythmic, submembrane, local Ca(2+) releases (LCR) that appear not at the MDP but during the late, diastolic depolarization (DD), defining a novel paradigm of robust cardiac pacemaker function and regulation. Expand
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TLDR
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Voltage Clamp Analysis of Latent Pacemaker Cells Isolated from Cat Right Atrium
TLDR
This work has shown that Ca2+-mediated inward sodium current in latent atrial pacemaker cells is a major cause of concern for future generations of pacemakers, and the proposed method to correct this problem is a viable and effective alternative. Expand
The arrhythmogenic current ITI in the absence of electrogenic sodium‐calcium exchange in sheep cardiac Purkinje fibres.
TLDR
The reversal potential suggests that ITI arises from a channel which is permeable to both potassium and calcium, and shows that at potentials more negative than the reversal potential of ITI, increasing tension is associated with increasing inward current and that the tension fluctuations follow current fluctuations by about 70 ms. Expand
Physiological Roles of the Rapidly Activated Delayed Rectifier K+ Current in Adult Mouse Heart Primary Pacemaker Activity
TLDR
Examination of patch clamp data of mouse SAN myocytes on the effects of a pharmacological blocker revealed that a rapidly activating K+ current is essential for action potential (AP) repolarization, and its deactivation during thepacemaker potential contributes a small but significant component to the pacemaker depolarization. Expand
Reciprocal interaction between IK1 and If in biological pacemakers: A simulation study
TLDR
A wide theoretical insight is provided into understandings for generating stable and robust pacemaker cells from non-pacemaking VMs by the interplay of IK1 and If, which may be helpful in designing engineered biological pacemakers for application purposes. Expand
cAMP-Dependent Signaling Restores AP Firing in Dormant SA Node Cells via Enhancement of Surface Membrane Currents and Calcium Coupling
TLDR
Transition of dormant SANC to AP firing is linked to the increased functional coupling of membrane and Ca2+ clock proteins, via an increase in cAMP-mediated phosphorylation of PLB accelerating Ca2+, and increased spatiotemporal LCR synchronization. Expand
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