The surmountable effect of FSCPX, an irreversible A1 adenosine receptor antagonist, on the negative inotropic action of A1 adenosine receptor full agonists in isolated guinea pig left atria

@article{Gesztelyi2013TheSE,
  title={The surmountable effect of FSCPX, an irreversible A1 adenosine receptor antagonist, on the negative inotropic action of A1 adenosine receptor full agonists in isolated guinea pig left atria},
  author={R. Gesztelyi and Z. Kiss and Zita Wachal and B{\'e}la Juh{\'a}sz and Mariann Bombicz and Evelin Cs{\'e}p{\'a}nyi and K. P{\'a}k and J. Zsuga and C. Papp and Z. Galajda and K. Brănzaniuc and R. P{\'o}rsz{\'a}sz and Andras Jozsef Szentmiklosi and {\'A}. T{\'o}saki},
  journal={Archives of Pharmacal Research},
  year={2013},
  volume={36},
  pages={293-305}
}
  • R. Gesztelyi, Z. Kiss, +11 authors Á. Tósaki
  • Published 2013
  • Biology, Medicine
  • Archives of Pharmacal Research
  • A1 adenosine receptors (A1 receptors) are widely expressed in mammalian tissues; therefore attaining proper tissue selectivity is a cornerstone of drug development. The fact that partial agonists chiefly act on tissues with great receptor reserve can be exploited to achieve an appropriate degree of tissue selectivity. To the best of our knowledge, the A1 receptor reserve has not been yet quantified for the atrial contractility. A1 receptor reserve was determined for the direct negative… CONTINUE READING
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