The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

@article{Yu2009TheSP,
  title={The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells},
  author={Xin Yu and Kristin Harden and Lino C. Gonzalez and Michelle R. Francesco and Eugene Y. Chiang and Bryan Irving and Irene Tom and Sinisa Ivelja and Canio J. Refino and Hilary F. Clark and Dan L. Eaton and Jane L. Grogan},
  journal={Nature Immunology},
  year={2009},
  volume={10},
  pages={48-57}
}
Here we have identified a surface protein, TIGIT, containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif that was expressed on regulatory, memory and activated T cells. Poliovirus receptor, which is expressed on dendritic cells, bound TIGIT with high affinity. A TIGIT-Fc fusion protein inhibited T cell activation in vitro, and this was dependent on the presence of dendritic cells. The binding of poliovirus receptor to TIGIT on… 
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