The surface protease PgtE of Salmonella enterica affects complement activity by proteolytically cleaving C3b, C4b and C5.

@article{Ramu2007TheSP,
  title={The surface protease PgtE of Salmonella enterica affects complement activity by proteolytically cleaving C3b, C4b and C5.},
  author={P{\"a}ivi Ramu and Rauna Tanskanen and Mikko T. Holmberg and Kaarina L{\"a}hteenm{\"a}ki and Timo K. Korhonen and Seppo Meri},
  journal={FEBS letters},
  year={2007},
  volume={581 9},
  pages={1716-20}
}
Complement activity in mammalian serum is fundamentally based on three homologous components C3b, C4b and C5. During systemic infection, the gastrointestinal pathogen Salmonella enterica disseminates within host phagocytic cells but also extracellularly. Consequently, systemic Salmonella transiently confronts the complement system. We show here that the… CONTINUE READING