The surface gene promoter of the human hepatitis B virus displays a preference for differentiated hepatocytes.

@article{Chang1989TheSG,
  title={The surface gene promoter of the human hepatitis B virus displays a preference for differentiated hepatocytes.},
  author={Hae Kyong Chang and Lap-hing. Ting},
  journal={Virology},
  year={1989},
  volume={170 1},
  pages={
          176-83
        }
}
By transfections of hepatitis B virus (HBV) DNA into five human hepatoma cell lines with the characteristics of differentiated human hepatocytes, three human hepatoma cell lines possessing partial hepatocyte-associated markers, and one non-liver cell line, we demonstrated that the expression of hepatitis B surface and core genes preferentially occurred in hepatoma cell lines with differentiated hepatocyte-associated characteristics. With a heterologous CAT gene as a reporter, the… CONTINUE READING
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