The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly.

@article{AcostaSerrano2001TheSC,
  title={The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly.},
  author={{\'A}lvaro Acosta-Serrano and Erik Vassella and Matthias Liniger and Christina Kunz Renggli and Reto Brun and Isabel Roditi and Paul T. Englund},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 4},
  pages={1513-8}
}
Trypanosoma brucei, the protozoan parasite causing sleeping sickness, is transmitted by a tsetse fly vector. When the tsetse takes a blood meal from an infected human, it ingests bloodstream form trypanosomes that quickly differentiate into procyclic forms within the fly's midgut. During this process, the parasite loses the 10(7) molecules of variant surface glycoprotein that formed its surface coat, and it develops a new coat composed of several million procyclin molecules. Procyclins, the… CONTINUE READING

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References

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Tsetse Control, Diagnosis, and Chemotherapy Using Nuclear Techniques (International Atomic Energy Agency, Vienna), IAEA-TECDOC-634

G. A. Cross, J. C. Manning
Z. Parasitenkd • 1988

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