The surface characterisation and comparison of two potential sub-micron, sugar bulking excipients for use in low-dose, suspension formulations in metered dose inhalers.

@article{James2008TheSC,
  title={The surface characterisation and comparison of two potential sub-micron, sugar bulking excipients for use in low-dose, suspension formulations in metered dose inhalers.},
  author={Jeff James and Barry Crean and Martyn Davies and Richard C Toon and P. V. Jinks and Clive J Roberts},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={361 1-2},
  pages={209-21}
}
PURPOSE This study compares the surface characteristics and surface energetics of two potential bulking excipients, anhydrous sub-micron alpha-lactose and sub-micron sucrose, for use with low-dose, suspension formulations in pressurised metered dose inhalers (pMDIs). Both sub-micron bulking excipients are processed from parent materials (alpha-lactose monohydrate/alpha-lactose monohydrate and silk grade sucrose, respectively) so the surface characteristics of each material were determined and… CONTINUE READING