The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis.

@article{Tennenbaum1993TheSE,
  title={The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis.},
  author={Tamar Tennenbaum and A. Weiner and Adam J. Belanger and Adam B. Glick and Henry Hennings and Stuart H. Yuspa},
  journal={Cancer research},
  year={1993},
  volume={53 20},
  pages={4803-10}
}
Enhanced expression of the alpha 6 beta 4 integrin complex has been linked to malignant progression in mouse skin carcinogenesis. To determine if alpha 6 beta 4 expression can predict risk for malignant conversion among populations of benign skin tumors, we analyzed the distribution of alpha 6 beta 4 and other markers of progression in papillomas at high and low risk for malignant progression. After initiation with 7,12-dimethylbenz[a]anthracene, mice were promoted with 12-O… CONTINUE READING
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