The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology.

@article{MacRae2006TheSO,
  title={The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology.},
  author={James I. MacRae and Samson O Obado and Daniel C. Turnock and Janine R Roper and Martin Kierans and John M. Kelly and Michael A. J. Ferguson},
  journal={Molecular and biochemical parasitology},
  year={2006},
  volume={147 1},
  pages={126-36}
}
The cell surface of the epimastigote form of Trypanosoma cruzi is covered by glycoconjugates rich in galactose. The parasite cannot take up galactose through its hexose transporter, suggesting that the epimerisation of UDP-glucose to UDP-galactose may be the parasite's only route to this sugar. The T. cruzi UDP-glucose 4'-epimerase is encoded by the TcGALE gene. We were unable to make a CL-Brener strain T. cruzi epimastigote TcGALE-/- null mutant, suggesting that the gene is essential. Two… CONTINUE READING

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