The suppressed expression and functional activity of hepatic P-glycoprotein in rats with protein-calorie malnutrition.

@article{Lee2003TheSE,
  title={The suppressed expression and functional activity of hepatic P-glycoprotein in rats with protein-calorie malnutrition.},
  author={Young-mi Lee and Im Sook Song and Sang Geon Kim and Myung Gull Lee and Suk-Jae Chung and Chang-koo Shim},
  journal={Journal of pharmaceutical sciences},
  year={2003},
  volume={92 7},
  pages={1323-30}
}
The effect of protein-calorie malnutrition (PCM) on the expression and functional activity of P-glycoprotein (P-gp) in the liver of rats was examined. Control protein diets and protein-restricted diets were fed to Sprague-Dawley rats for 4 weeks, and the expression of P-gp in the liver (Western blot), in vitro uptake of a representative substrate of P-gp, daunomycin, into canalicular liver plasma membrane (cLPM) vesicles, and in vivo canalicular excretion of daunomycin were compared between the… CONTINUE READING