The supplementary diagnostic power of selected immunohistochemical, molecular genetic and infective parameters in epithelial hyperplastic laryngeal lesions.

@article{Kleist2003TheSD,
  title={The supplementary diagnostic power of selected immunohistochemical, molecular genetic and infective parameters in epithelial hyperplastic laryngeal lesions.},
  author={Britta Kleist and D. T. Junghans and Gerd Lorenz and Alexander Bankau and Micaela Poetsch},
  journal={Oncology},
  year={2003},
  volume={65 4},
  pages={347-54}
}
OBJECTIVES MIB-1 and p53 protein expression, loss of heterozygosity (LOH), microsatellite instability (MSI) of di- and mononucleotide repeats, and HPV status were tested for their potential to characterize different stages of epithelial hyperplastic laryngeal lesions (EHLL). METHODS Thirty-two EHLL were reclassified according to the Ljubljana classification into simple (SH), abnormal (AbH), atypical hyperplasia (AtH) and carcinoma in situ, and investigated by immunohistochemical methods, PCR… CONTINUE READING

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