The superiority of hamster liver microsomal fraction for activating nitrosamines to mutagens in Salmonella typhimurium.


A number of nitrosamines which were carcinogenic in rats were not activated to mutagens in the Salmonella/mammalian microsome assay by the addition of the rat liver microsomal fraction. Some of these nitrosamines induced tumors in the liver of rats and others were carcinogenic to different organs of the rat. Most of these nitrosamines were activated to… (More)


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