The superfamily of organic anion transporting polypeptides.

  title={The superfamily of organic anion transporting polypeptides.},
  author={Bruno Hagenbuch and Peter Meier},
  journal={Biochimica et biophysica acta},
  volume={1609 1},
Organic anion transporting polypeptides (Oatps/OATPs) form a growing gene superfamily and mediate transport of a wide spectrum of amphipathic organic solutes. Different Oatps/OATPs have partially overlapping and partially distinct substrate preferences for organic solutes such as bile salts, steroid conjugates, thyroid hormones, anionic oligopeptides, drugs, toxins and other xenobiotics. While some Oatps/OATPs are preferentially or even selectively expressed in one tissue such as the liver… CONTINUE READING
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