The suicidal DNA repair methyltransferases of microbes.

  title={The suicidal DNA repair methyltransferases of microbes.},
  author={Leona D. Samson},
  journal={Molecular microbiology},
  volume={6 7},
Virtually every organism so far tested has been found to possess an extremely efficient DNA repair mechanism to ensure that certain alkylated oxygens do not accumulate in the genome. The repair is executed by DNA methyltransferases (MTases) which repair DNA O6-methylguanine (O6MeG), O4-methylthymine (O4MeT) and methylphosphotriesters (MePT). The mechanism is rather extravagant because an entire protein molecule is expended for the repair of just one, or sometimes two, O-alkyl DNA adduct(s… CONTINUE READING

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