The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease

@article{Mimura2010TheSK,
  title={The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease},
  author={Imari Mimura and Masaomi Nangaku},
  journal={Nature Reviews Nephrology},
  year={2010},
  volume={6},
  pages={667-678}
}
Chronic kidney disease (CKD) is characterized by irreversible pathological processes that result in the development of end-stage renal disease (ESRD). Accumulating evidence has emphasized the important role of chronic hypoxia in the tubulointerstitium in the final common pathway that leads to development of ESRD. The causes of chronic hypoxia in the tubulointerstitium are multifactorial and include mechanisms such as hemodynamic changes and disturbed oxygen metabolism of resident kidney cells… CONTINUE READING

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