The successful long-term treatment of age related erectile dysfunction with hSlo cDNA in rats in vivo.

@article{Melman2003TheSL,
  title={The successful long-term treatment of age related erectile dysfunction with hSlo cDNA in rats in vivo.},
  author={Arnold Melman and Weixin Zhao and Kelvin P Davies and Ron Bakal and George J. Christ},
  journal={The Journal of urology},
  year={2003},
  volume={170 1},
  pages={285-90}
}
PURPOSE We have previously reported that 1 intracorporeal injection of 100 microg hSlo/pcDNA reversed the effect of aging on erectile function in a rat model in vivo for at least 2 months. We report our further investigations of the amplitude, duration and physiological relevance of this novel gene transfer approach. MATERIALS AND METHODS A total of 191 retired breeder Sprague-Dawley rats were given a single intracavernous injection of phosphate buffered saline, 1,000 microg pcDNA, or 10, 100… CONTINUE READING

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