The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.

@article{Tsuge2001TheS1,
  title={The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.},
  author={Tomohiko Tsuge and Minami Matsui and Ning Wei},
  journal={Journal of molecular biology},
  year={2001},
  volume={305 1},
  pages={
          1-9
        }
}
The COP9 signalosome is a conserved protein complex composed of eight subunits. Individual subunits of the complex have been linked to various signal transduction pathways leading to gene expression and cell cycle control. However, it is not understood how each subunit executes these activities as part of a large protein complex. In this study, we dissected structure and function of the subunit 1 (CSN1 or GPS1) of the COP9 signalosome relative to the complex. We demonstrated that the C-terminal… 

Figures from this paper

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The Minimal Deneddylase Core of the COP9 Signalosome Excludes the Csn6 MPN− Domain

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Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development

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The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis.

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...

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