The subthalamic nucleus in the context of movement disorders.

@article{Hamani2004TheSN,
  title={The subthalamic nucleus in the context of movement disorders.},
  author={Clement Hamani and Jean A. Saint-Cyr and Justin F Fraser and Michael G. Kaplitt and Andres M. Lozano},
  journal={Brain : a journal of neurology},
  year={2004},
  volume={127 Pt 1},
  pages={4-20}
}
The subthalamic nucleus (STN) has been regarded as an important modulator of basal ganglia output. It receives its major afferents from the cerebral cortex, thalamus, globus pallidus externus and brainstem, and projects mainly to both segments of the globus pallidus, substantia nigra, striatum and brainstem. The STN is essentially composed of projection glutamatergic neurons. Lesions of the STN induce choreiform abnormal movements and ballism on the contralateral side of the body. In animal… CONTINUE READING
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