The subthalamic nucleus in primary dystonia: single-unit discharge characteristics.

@article{Schrock2009TheSN,
  title={The subthalamic nucleus in primary dystonia: single-unit discharge characteristics.},
  author={Lauren E. Schrock and Jill Louise Ostrem and Robert S. Turner and Shoichi A Shimamoto and Philip A. Starr},
  journal={Journal of neurophysiology},
  year={2009},
  volume={102 6},
  pages={3740-52}
}
Most models of dystonia pathophysiology predict alterations of activity in the basal ganglia thalamocortical motor circuit. The globus pallidus interna (GPi) shows bursting and oscillatory neuronal discharge in both human dystonia and in animal models, but it is not clear which intrinsic basal ganglia pathways are implicated in this abnormal output. The subthalamic nucleus (STN) receives prominent excitatory input directly from cortical areas implicated in dystonia pathogenesis and inhibitory… CONTINUE READING

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