The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca

@inproceedings{Sayer2014TheSS,
  title={The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca},
  author={C. Sayer and Rub{\'e}n J. Mart{\'i}nez-Torres and Nina Richter and Michail N. Isupov and Helen C Hailes and Jennifer A. Littlechild and John M Ward},
  booktitle={The FEBS journal},
  year={2014}
}
UNLABELLED During the last decade the use of transaminases for the production of pharmaceutical and fine chemical intermediates has attracted a great deal of attention. Transaminases are versatile biocatalysts for the efficient production of amine intermediates and many have (S)-enantiospecificity. Transaminases with (R)-specificity are needed to expand the applications of these enzymes in biocatalysis. In this work we have identified a fungal putative (R)-specific transaminase from the… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 47 references

Asymmetric amination of tetralone and chromanone

  • D Pressnitz, CS Fuchs, +4 authors W Kroutil
  • 2013

Asymmetric amination of tetralone and chromanone derivatives employing w - transaminases

  • D Pressnitz, CS Fuchs, +4 authors W Kroutil
  • ACS Catal
  • 2013

Crystallization and preliminary X-ray diffraction studies of the (R)selective amine transaminase from Aspergillus fumigatus

  • M ohne, UT Bornscheuer, W Hinrichs
  • Acta Crystallogr Sect F Struct Biol Cryst
  • 2013

Crystal structures of the Chromobacterium violaceum w - transaminase reveal major structural rearrangements upon binding of coenzyme PLP

  • MS Humble, KE Cassimjee, +5 authors DT Logan
  • FEBS J
  • 2012

Crystal structures of the Chromobacterium violaceum w-transaminase reveal major structural rearrangements upon binding

  • MS Humble, KE Cassimjee, +6 authors DT Logan
  • 2012

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