The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease.

@article{Damier1999TheSN,
  title={The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease.},
  author={Philippe Damier and Etienne C. Hirsch and Yves Agid and Ann M. Graybiel},
  journal={Brain : a journal of neurology},
  year={1999},
  volume={122 ( Pt 8)},
  pages={1437-48}
}
To achieve accuracy in studying the patterns of loss of midbrain dopamine-containing neurons in Parkinson's disease, we used compartmental patterns of calbindin D(28K) immunostaining to subdivide the substantia nigra with landmarks independent of the degenerative process. Within the substantia nigra pars compacta, we identified dopamine-containing neurons in the calbindin-rich regions ('matrix') and in five calbindin-poor pockets ('nigrosomes') defined by analysis of the three-dimensional… CONTINUE READING
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