The subnucleus reticularis dorsalis is involved in antinociception produced by a low dose of naloxone during carrageenan-induced inflammation

  title={The subnucleus reticularis dorsalis is involved in antinociception produced by a low dose of naloxone during carrageenan-induced inflammation},
  author={Masayoshi Tsuruoka and Yukiko Hiruma and William D. Willis},
  journal={Brain Research},

Involvement of the locus coeruleus in analgesic effects of a low dose of naloxone during the inflammatory process

It is suggested that the LC is involved in naloxone-induced antinociception during the early phase of inflammation, as well as in sham-operated rats, under conditions of unilateral inflammation.

Activation of silent mechanoreceptive cat C and Aδ sensory neurons and their substance P expression following peripheral inflammation

A combined increases in the excitability of DRG neurons and SP‐containing RF‐responsive neurons could lead to sensitization of sensory neurons, thus contributing to the development of hyperalgesia.

A Double-blind, Placebo-controlled Study on the Effect of Buprenorphine and Fentanyl on Descending Pain Modulation: A Human Experimental Study

The opioids buprenorphine and fentanyl significantly potentiate the effect of descending pain inhibition in healthy volunteers, with no differences between the 2 active drugs.

Effect of Administration of an Opioid Antagonist (Naloxane) to Treat Ovarian Cysts in Dairy Cows

The results of this study showed that Naloxane was better than the other two groups to treat follicular cysts, but there was no significant difference in differnnt criteria, such as CL formation, increasing plasma P4 concentrations and 1st service conception rates among 3 groups.

Preliminary study on the effect of parenteral naloxone, alone and in association with calcium gluconate, on bone healing in an ovine "drill hole" model system

A low-dose parenteral regimen of naloxone enhances mineralization and remodelling of the callus in healing cortical defects in sheep, especially if associated with calcium gluconate.

Defining projections from the caudal pressor area of the caudal ventrolateral medulla

It is concluded that the caudal pressor area (CPA) projects preferentially to the subnucleus reticularis dorsalis, commissural nucleus tractus solitarii, lateral medulla, A5 area, and internal lateral parabrachial nucleus, which implies a unique role for the CPA in somatoautonomic regulation.

New Formulation of Sustained Release Naloxone Can Reverse Opioid Induced Constipation Without Compromising the Desired Opioid Effects.

This Phase II study has shown that using a new sustained release formulation to deliver oral naloxone to the colon allows successful treatment of OIC without comprising the desired opioid effects.

Effect of an enteric‐release formulation of naloxone on intestinal transit in volunteers taking codeine

Constipation is a common side‐effect of opioid therapy; in addition to their analgesic effect, opioids reduce intestinal secretion and motility with an increase in whole‐gut transit time. Naloxone, a



Naloxone alters pain perception and somatosensory evoked potentials in normal subjects

Results suggest that individual differences in pain sensitivity may relate to differences in an endorphin system, and naloxone administered to man should alter pain appreciation.

Ascending pathways in the spinal cord involved in the activation of subnucleus reticularis dorsalis neurons in the medulla of the rat.

The findings suggest that lamina I nociceptive specific neurons, the axons of which travel within the dorsolateral funiculus, do not contribute very much to the activation of SRD neurons, and conclude that the signals responsible for the activated neurons travel principally in the lateral parts of the ventrolateral quadrant.

Paradoxical analgesia produced by low doses of the opiate-antagonist naloxone is mediated by interaction at a site with characteristics of the delta opioid receptor.

It is concluded that the analgesic action of a low dose of naloxone is mediated via interaction with a stereospecific binding site with the characteristics of the delta-opioid receptor.