The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains.

@article{Lin2014TheSA,
  title={The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains.},
  author={Ting-Feng Lin and I-Wen Lin and Shu-Ching Chen and Hao-Han Wu and Chi-Sheng Yang and Hsin-Yu Fang and M. Chiu and C Jeng},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 33},
  pages={22815-34}
}
A functional voltage-gated K(+) (Kv) channel comprises four pore-forming α-subunits, and only members of the same Kv channel subfamily may co-assemble to form heterotetramers. The ether-à-go-go family of Kv channels (KCNH) encompasses three distinct subfamilies: Eag (Kv10), Erg (Kv11), and Elk (Kv12). Members of different ether-à-go-go subfamilies, such as Eag and Erg, fail to form heterotetramers. Although a short stretch of amino acid sequences in the distal C-terminal section has been… CONTINUE READING

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