The subendothelium of the HMEC-1 cell line supports thrombus formation in the absence of von Willebrand factor and collagen types I, III and VI.

@article{Bonnefoy2001TheSO,
  title={The subendothelium of the HMEC-1 cell line supports thrombus formation in the absence of von Willebrand factor and collagen types I, III and VI.},
  author={Arnaud Bonnefoy and Jol{\'a}n H{\'a}rsfalvi and Gy{\"o}rgy Pfliegler and Françoise Fauvel-Laf{\`e}ve and Chantal Legrand},
  journal={Thrombosis and haemostasis},
  year={2001},
  volume={85 3},
  pages={552-9}
}
The macromolecular composition of the extracellular matrix (ECM) produced by the human microvascular endothelial cell line (HMEC-1) was determined by ELISA and its thrombogenicity was studied in blood perfusion assays. Results were compared with those obtained with the ECM produced by human umbilical vein endothelial cells (HUVEC). The HMEC-1's ECM contains collagen type IV, fibronectin, laminin and thrombospondin, but no detectable levels of collagen types I, III and VI, or von Willebrand… CONTINUE READING

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