The subcellular localization of vaccinia‐related kinase‐2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

@article{Blanco2006TheSL,
  title={The subcellular localization of vaccinia‐related kinase‐2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines},
  author={S. Blanco and L. Klim{\vc}{\'a}kov{\'a} and F. M. Vega and P. Lazo},
  journal={The FEBS Journal},
  year={2006},
  volume={273}
}
VRK is a new kinase family of unknown function. Endogenous human vacinia‐related kinase 2 (VRK2) protein is present in both the nucleus and the cytosol, which is a consequence of alternative splicing of two VRK2 messages coding for proteins of 508 and 397 amino acids, respectively. VRK2A has a C‐terminal hydrophobic region that anchors the protein to membranes in the endoplasmic reticulum (ER) and mitochondria, and it colocalizes with calreticulin, calnexin and mitotracker; whereas VRK2B is… Expand
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