The sua8 suppressors of Saccharomyces cerevisiae encode replacements of conserved residues within the largest subunit of RNA polymerase II and affect transcription start site selection similarly to sua7 (TFIIB) mutations.

@article{Berroteran1994TheSS,
  title={The sua8 suppressors of Saccharomyces cerevisiae encode replacements of conserved residues within the largest subunit of RNA polymerase II and affect transcription start site selection similarly to sua7 (TFIIB) mutations.},
  author={R W Berroteran and D E Ware and Michael Hampsey},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 1},
  pages={226-37}
}
Mutations in the Saccharomyces cerevisiae sua8 gene were found to be suppressors of an aberrant ATG translation initiation codon in the leader region of the cyc1 gene. Analysis of cyc1 transcripts from sua8 mutants revealed that suppression is a consequence of diminished transcription initiation at the normal start sites in favor of initiation at downstream sites, including a site between the aberrant and normal ATG start codons. This effect is not cyc1 gene specific since initiation at other… CONTINUE READING

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Synthetic lethality was associated with double sua7 sua8 suppressor mutations , and recessive sua7 mutants failed to fully complement recessive sua8 mutants in heterozygous diploids ( nonallelic noncomplementation ) .
Synthetic lethality was associated with double sua7 sua8 suppressor mutations , and recessive sua7 mutants failed to fully complement recessive sua8 mutants in heterozygous diploids ( nonallelic noncomplementation ) .
Synthetic lethality was associated with double sua7 sua8 suppressor mutations , and recessive sua7 mutants failed to fully complement recessive sua8 mutants in heterozygous diploids ( nonallelic noncomplementation ) .
Synthetic lethality was associated with double sua7 sua8 suppressor mutations , and recessive sua7 mutants failed to fully complement recessive sua8 mutants in heterozygous diploids ( nonallelic noncomplementation ) .
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