The study on interactions between levofloxacin and model proteins by using multi-spectroscopic and molecular docking methods.

@article{Fang2018TheSO,
  title={The study on interactions between levofloxacin and model proteins by using multi-spectroscopic and molecular docking methods.},
  author={Qing Fang and Chenhui Guo and Yirun Wang and Ying Liu},
  journal={Journal of biomolecular structure & dynamics},
  year={2018},
  volume={36 8},
  pages={2032-2044}
}
The interactions of levofloxacin (LEV) with lysozyme (LYZ), trypsin and bovine hemoglobin (BHb) were investigated, respectively, by using multi-spectral techniques and molecular docking in vitro. Fluorescence studies showed that LEV quenched LYZ/trypsin fluorescence in a combined quenching ways and BHb fluorescence in a static quenching with binding constants of .14, .51 and .20 × 105 L mol-1 at 298 K, respectively. The thermodynamic parameters demonstrated that hydrophobic forces, hydrogen… CONTINUE READING

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