[The study of the association of polymorphism rs659366 gene UCP2 c obesity and type 2 diabetes among residents of the Moscow Region].

Abstract

1112 people from Moscow region have been surveyed. Genotyping of rs659366 polymorphism UCP2 gene was performed using allele-specific amplification, result detection in real time and using TaqMan-probes complementary DNA polymorphic sites. The study of rs659366 polymorphism of the UCP2 gene has showed that 36.9% of patients had genotype AA, 46.7%--genotype AG, and 16.5%--genotype GG. The frequency of allele A was 60.2%, allele G--39.8%. BMI, value of fat mass, visceral fat area, serum glucose and triglyceride levels were significantly higher in carriers of A allele in the homozygous and heterozygous state than in carriers of G allele in the homozygous state. Frequency of A allele compared with G allele in obese patients (BMI greater than 30 kg/m2) was: OR--1.52; CI (1.24-1.86), p = 0.001, and in diabetes mellitus type 2--OR--1.22; CI (0.910-1.622), p = 0.19.

Cite this paper

@article{Baturin2015TheSO, title={[The study of the association of polymorphism rs659366 gene UCP2 c obesity and type 2 diabetes among residents of the Moscow Region].}, author={Alexander K Baturin and E Yu Sorokina and A. V. Pogozheva and E V Peskova and O. N. Makurina and Victor A. Tutelyan}, journal={Voprosy pitaniia}, year={2015}, volume={84 1}, pages={44-9} }