The study of eQTL variations by RNA-seq: from SNPs to phenotypes.

@article{Majewski2011TheSO,
  title={The study of eQTL variations by RNA-seq: from SNPs to phenotypes.},
  author={Jacek Majewski and Tomi Pastinen},
  journal={Trends in genetics : TIG},
  year={2011},
  volume={27 2},
  pages={72-9}
}
Common DNA variants alter the expression levels and patterns of many human genes. Loci responsible for this genetic control are known as expression quantitative trait loci (eQTLs). The resulting variation of gene expression across individuals has been postulated to be a determinant of phenotypic variation and susceptibility to complex disease. In the past, the application of expression microarray and genetic variation data to study populations enabled the rapid identification of eQTLs in model… CONTINUE READING