The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificities.

@article{Leiman2007TheSO,
  title={The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificities.},
  author={Petr G Leiman and Anthony J. Battisti and Valorie D. Bowman and Katharina Stummeyer and Martina M{\"u}hlenhoff and Rita Gerardy-Schahn and Dean Scholl and Ian J. Molineux},
  journal={Journal of molecular biology},
  year={2007},
  volume={371 3},
  pages={836-49}
}
External polysaccharides of many pathogenic bacteria form capsules protecting the bacteria from the animal immune system and phage infection. However, some bacteriophages can digest these capsules using glycosidases displayed on the phage particle. We have utilized cryo-electron microscopy to determine the structures of phages K1E and K1-5 and thereby… CONTINUE READING