The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly


Tubulin-binding cofactor A (TBCA) participates in microtubule formation, a key process in eukaryotic biology to create the cytoskeleton. There is little information on how TBCA might interact with β-tubulin en route to microtubule biogenesis. To address this, the protozoan Leishmania major was targeted as a model system. The crystal structure of TBCA and… (More)
DOI: 10.1107/S2053230X15000990


5 Figures and Tables