The structure of the protein universe and genome evolution

@article{Koonin2002TheSO,
  title={The structure of the protein universe and genome evolution},
  author={Eugene V. Koonin and Yuri I. Wolf and Georgy P. Karev},
  journal={Nature},
  year={2002},
  volume={420},
  pages={218-223}
}
Despite the practically unlimited number of possible protein sequences, the number of basic shapes in which proteins fold seems not only to be finite, but also to be relatively small, with probably no more than 10,000 folds in existence. Moreover, the distribution of proteins among these folds is highly non-homogeneous — some folds and superfamilies are extremely abundant, but most are rare. Protein folds and families encoded in diverse genomes show similar size distributions with notable… CONTINUE READING
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