The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling.

@article{Lau2009TheSO,
  title={The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling.},
  author={Tong-Lay Lau and Chungho Kim and Mark H Ginsberg and Tobias S Ulmer},
  journal={The EMBO journal},
  year={2009},
  volume={28 9},
  pages={1351-61}
}
Heterodimeric integrin adhesion receptors regulate cell migration, survival and differentiation in metazoa by communicating signals bi-directionally across the plasma membrane. Protein engineering and mutagenesis studies have suggested that the dissociation of a complex formed by the single-pass transmembrane (TM) segments of the alpha and beta subunits is central to these signalling events. Here, we report the structure of the integrin alphaIIbbeta3 TM complex, structure-based site-directed… CONTINUE READING
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