The structure of the genotype-phenotype map strongly constrains the evolution of non-coding RNA.

@article{Dingle2015TheSO,
  title={The structure of the genotype-phenotype map strongly constrains the evolution of non-coding RNA.},
  author={Kamaludin Dingle and Steffen Schaper and Ard A. Louis},
  journal={Interface focus},
  year={2015},
  volume={5 6},
  pages={20150053}
}
The prevalence of neutral mutations implies that biological systems typically have many more genotypes than phenotypes. But, can the way that genotypes are distributed over phenotypes determine evolutionary outcomes? Answering such questions is difficult, in part because the number of genotypes can be hyper-astronomically large. By solving the genotype-phenotype (GP) map for RNA secondary structure (SS) for systems up to length L = 126 nucleotides (where the set of all possible RNA strands… CONTINUE READING
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