The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.

@article{Gattis2006TheSO,
  title={The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.},
  author={James L Gattis and Anthony V. Washington and Maia M Chisholm and Laura Quigley and Agnieszka Szyk and Daniel W McVicar and Jacek T Lubkowski},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 19},
  pages={13396-403}
}
Triggering receptor expressed on myeloid cells like transcript-1 (TLT-1) is an abundant platelet-specific, type I transmembrane receptor. The extracellular fragment of TLT-1 consists of a single, immunoglobulin-like domain connected to the platelet cell membrane by a linker region called the stalk. Here we present evidence that a soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following… CONTINUE READING

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