The structure of the dorsal raphe nucleus and its relevance to the regulation of sleep and wakefulness.

@article{Monti2010TheSO,
  title={The structure of the dorsal raphe nucleus and its relevance to the regulation of sleep and wakefulness.},
  author={Jaime M. Monti},
  journal={Sleep medicine reviews},
  year={2010},
  volume={14 5},
  pages={
          307-17
        }
}
  • J. Monti
  • Published 1 October 2010
  • Biology
  • Sleep medicine reviews
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doi.org
95 Citations
Highly Influential Citations
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95 Citations

Serotonergic Systems in Sleep and Waking
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Functional Interaction Between GABAergic Neurons in the Ventral Tegmental Area and Serotonergic Neurons in the Dorsal Raphe Nucleus
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It is found that VTAGad67+ neurons were integrated in many inputs, and their output inhibits DRN5–HT neurons, which may regulate physiological functions including sleep/wakefulness.
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It is hypothesized that the interactions of these opposite but complementary hypothalamic systems are critical for the generation of either wakefulness or sleep.
The modulation of the spatial reference memory by the orexinergic system of the dorsal raphe nucleus.
The 5-hydroxytryptaminergic Neurons Locating in the Dorsal Raphe Nucleus and Different Receptors of 5-HT Were Implicated in Mediating the Arousal from Sevoflurane Anesthesia
TLDR
Through intraventricular infusion and intranuclear microinjection of serotonin and 5-HT receptor agonists or antagonists, study shows that serotonin and5-HT 1A and 2A/C receptor, especially 5- HT 1A receptor, are involved in the regulation of awakening delay mediated by DRN 5-ht neurons.
The cholinergic agonist carbachol increases the frequency of spontaneous GABAergic synaptic currents in dorsal raphe serotonergic neurons in the mouse
Serotonin2B receptors in the rat dorsal raphe nucleus exert a GABA-mediated tonic inhibitory control on serotonin neurons
Differential expression of serotonin2B receptors in GABAergic and serotoninergic neurons of the rat and mouse dorsal raphe nucleus
Unilateral lesion of the nigrostriatal pathway decreases the response of GABA interneurons in the dorsal raphe nucleus to 5-HT1A receptor stimulation in the rat
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References

SHOWING 1-10 OF 141 REFERENCES
Serotonin and sleep : molecular, functional and clinical aspects
TLDR
Serotonergic mechanisms contributing to arousal and alerting, and contribution of chemosensitive serotonergic neurons to interactions between the sleep-wake cycle and respiratory control are studied.
Cellular basis for the effects of substance P in the periaqueductal gray and dorsal raphe nucleus
TLDR
The distribution of the principal receptor for SP, the neurokinin 1 (NK1) receptor, was examined with respect to other neurotransmitter markers and data suggest that SP directly acts primarily on glutamatergic neurons in the PAG and DRN.
Chemoarchitecture of the primate dorsal raphe nucleus
Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons.
TLDR
It is shown in the unanesthetized rat that the iontophoretic application of the GABA(A) antagonist bicuculline on dorsal raphe serotonergic neurons induces a tonic discharge during SWS and PS and an increase of discharge rate during quiet waking.
Effects of Corticotropin-Releasing Factor on Neuronal Activity in the Serotonergic Dorsal Raphe Nucleus
Efferent and afferent connections of the dorsal and median raphe nuclei in the rat
TLDR
The dorsal raphe and median raphe nuclei are positioned to integrate of vast array of information from the brainstem and limbic forebrain and through their extensive axonal network influence virtually all parts of the neuroaxis.
Topography of serotonin neurons in the dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus accumbens
Mechanisms involved in the inhibition of REM sleep by serotonin
TLDR
It is proposed that the DOI activation of long-projection GABAergic neurons that express 5-HT2A/2C receptors would be responsible for the inhibition of cholinergic cells in the laterodorsal tegmental and pedunculopontine te segmental nuclei (LDT/PPT) and the suppression of REMS.
Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies
A Neurochemically Distinct Dorsal Raphe-Limbic Circuit with a Potential Role in Affective Disorders
TLDR
A circuit whereby NK1 receptor activation in the dorsomedial DR can impact on limbic sources of CRF that have been implicated in emotional responses is revealed, relevant for understanding the mechanism of action of novel psychotherapeutic agents that act through NK1 or CRF receptors.
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