The structure of the CRISPR-associated protein Csa3 provides insight into the regulation of the CRISPR/Cas system.

@article{Lintner2011TheSO,
  title={The structure of the CRISPR-associated protein Csa3 provides insight into the regulation of the CRISPR/Cas system.},
  author={Nathanael G Lintner and Kenneth A. Frankel and Susan E. Tsutakawa and Donald L Alsbury and Val{\'e}rie Copi{\'e} and Mark J. Young and John A. Tainer and C. Martin Lawrence},
  journal={Journal of molecular biology},
  year={2011},
  volume={405 4},
  pages={
          939-55
        }
}
Adaptive immune systems have recently been recognized in prokaryotic organisms where, in response to viral infection, they incorporate short fragments of invader-derived DNA into loci called clustered regularly interspaced short palindromic repeats (CRISPRs). In subsequent infections, the CRISPR loci are transcribed and processed into guide sequences for the neutralization of the invading RNA or DNA. The CRISPR-associated protein machinery (Cas) lies at the heart of this process, yet many of… CONTINUE READING
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