The structure of rat liver vault at 3.5 angstrom resolution.

@article{Tanaka2009TheSO,
  title={The structure of rat liver vault at 3.5 angstrom resolution.},
  author={Hideaki Tanaka and Koji Kato and Eiki Yamashita and Tomoyuki Sumizawa and Yong Zhou and Min Yao and Kenji Iwasaki and Masato Yoshimura and Tomitake Tsukihara},
  journal={Science},
  year={2009},
  volume={323 5912},
  pages={
          384-8
        }
}
Vaults are among the largest cytoplasmic ribonucleoprotein particles and are found in numerous eukaryotic species. Roles in multidrug resistance and innate immunity have been suggested, but the cellular function remains unclear. We have determined the x-ray structure of rat liver vault at 3.5 angstrom resolution and show that the cage structure consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains. Each MVP monomer folds into 12… CONTINUE READING

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