• Corpus ID: 36345093

The structure of psychopharmacological revolutions.

  title={The structure of psychopharmacological revolutions.},
  author={David Healy},
  journal={Psychiatric developments},
  volume={5 4},
  • D. Healy
  • Published 1987
  • Psychology
  • Psychiatric developments
Thomas Kuhn's model of the structure of scientific procedure is outlined and applied to salient aspects of recent psychopharmacological research into the bioneural substrates of the affective disorders. It is argued that the amine hypotheses of these disorders are irrefutable in practice although not in principle and that their survival despite a lack of convincing supporting evidence and dis-proof of their initial premises suggests that they serve a paradigmatic function and that the core of… 

The Serotonin Hypothesis of Schizophrenia: A Historical Case Study on the Heuristic Value of Theory in Clinical Neuroscience

It is shown that the original serotonin hypothesis of schizophrenia did, in fact, lead to significant advances in neuropharmacology, neurology and psychiatry.

Continuity and Discontinuity in the Historical Development of Modern Psychopharmacology

Evidence is presented that psychoanalysis did not constitute a paradigm and that the advent of psychopharmacology was not, technically, a scientific revolution; instead, the rise of modern psychopharmaology was the culmination of a linear growth of biological knowledge that began to develop in the nineteenth century.

Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders

  • D. Healy
  • Psychology
  • 2004
Evidence is presented supportive of the notion that the pathophysiology of the Affective disorders involves a disruption of circadian rhythms and that the primary locus of action of agents effective in the affective disorders is on the circadian rhythm system.

The psychopharmacological era: notes toward a history

  • D. Healy
  • Psychology
    Journal of psychopharmacology
  • 1990
Cultural and economic influences on the psychopharmacological era are reviewed, in an attempt to bring into focus what has been happening in psychopharmacology for the past thirty years. It is argued

The Fluoxetine and Suicide Controversy

  • D. Healy
  • Psychology, Medicine
    CNS drugs
  • 1994
Evidence is emerging that a range of psychotropic drugs may precipitate akathisia and/or panic reactions in predisposed patients and the serotonin (5-hydroxytryptarnine; 5-HT) system may be involved in these reactions.

The comparative psychopathology of affective disorders in animals and humans

  • D. Healy
  • Psychology
    Journal of psychopharmacology
  • 1987
The psychopathological tradition stemming from Jaspers may be more appropriate to a consideration of animal models of affective disorders than the psychopathological positions implicit in psychoanalysis, behaviourism or current cognitive psychologies and in addition more suited to meet current operational criteria for the diagnosis of major depressive disorders.

Solving the crisis in psychopharmacological research: Cellular-membrane(s) pharmacology to the rescue?

Ethical issues in psychopharmacology

Ethical issues relating to the efficacy and safety of selective serotonin reuptake inhibitors and their marketing in the psychopharmacological industry are examined.

Reboxetine: its effects as measured by the Social Adaptation Self‐evaluation Scale

  • D. Healy
  • Psychology
    Acta psychiatrica Scandinavica. Supplementum
  • 2000
The findings suggest that while some patients may appear to the clinician to have recovered, they may remain less than fully well and differences in selectivity for neurotransmitter systems may play a part in the degree of wellbeing that recovered patients might expect.

Ideology over evidence?

Dr Moncrieff’s narrative is selective at best, and on cursory examination there is little effort to appraise the literature in a scientifically objective manner, suggesting that this opinion piece represents ideology over evidence.



Psychiatric Indications for Clonidine: The Neuropharmacologic and Clinical Basis

  • W. Bond
  • Psychology, Medicine
    Journal of clinical psychopharmacology
  • 1986
Evidence which suggests that clonidine can reduce the duration and cost of the withdrawal process and its efficacy as an antimanic agent and treatment for tardive dyskinesia is particularly exciting and worthy of further study.

Neurosis, psychodynamics, and DSM-III. A history of the controversy.

A narrative account of the controversies over the role of psychodynamic formulations in DSM-III and the more focused, though sharply contested, symbolic dispute over the inclusion of neurosis in the nomenclature is presented.

Normothymotics, “Mood-Normalizers”

  • M. Schou
  • Psychology, Medicine
    British Journal of Psychiatry
  • 1963
Normothymotics, “mood-normalizers”, is proposed as a collective name for drugs belonging to a group that is characterized by being active against affective disorders (manic-depressive psychosis), and evidence will be presented for the existence of this class of a group.

The Diagnosis of Depressive Syndromes and the Prediction of E.C.T. Response

There is evidence to indicate that the uncertainty about the most clear and convenient lines of demarcation within this clinical territory makes a large contribution to the unreliability of psychiatric diagnosis.

Monoamine transport in depression: kinetics and dynamics.

An anatomy of schizophrenia?

  • J. Stevens
  • Psychology, Biology
    Archives of general psychiatry
  • 1973
Anatomic and physiologic studies indicate that limbic striatum resembles caudate putamen not only in ultrastructure and histochemistry, but also as a recipient of efferents from limbic cortex, amygdala, and hippocampus in a pattern that remarkably parallels the projections of neocortex on neostriatum.

The psychopathology of affectivity: conceptual and historical aspects

This paper shows how the subordinate role played by affectivity in the Western concept of man led to the early and enduring view of mental illness as an exclusive disturbance of intellect.

Endogenomorphic depression. A conceptual and terminological revision.

  • D. Klein
  • Psychology
    Archives of general psychiatry
  • 1974
This report reviews conflicts in delineating the phenomena of depression with an emphasis on the central criterion role of the symptomatic pattern of the nonprecipitated (endogenous) depression.

New Evidence of Serotonin-Deficient Depressions

If the central 5-HT turnover is diminished in depressions, then correction of this biochemical disturbance leads to alleviation of depressive symptoms and the concept of ‘5-HT-deficient depression’ is supported.