The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity.

@article{Okorokov2006TheSO,
  title={The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity.},
  author={Andrei L. Okorokov and Michael B. Sherman and C{\'e}lia Plisson and Vera Grinkevich and Kristmundur Sigmundsson and Galina A. Selivanova and Jo Milner and Elena V Orlova},
  journal={The EMBO journal},
  year={2006},
  volume={25 21},
  pages={
          5191-200
        }
}
p53 major tumour suppressor protein has presented a challenge for structural biology for two decades. The intact and complete p53 molecule has eluded previous attempts to obtain its structure, largely due to the intrinsic flexibility of the protein. Using ATP-stabilised p53, we have employed cryoelectron microscopy and single particle analysis to solve the first three-dimensional structure of the full-length p53 tetramer (resolution 13.7 A). The p53 molecule is a D2 tetramer, resembling a… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 42 CITATIONS

Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC

Yaqun Zhang, Lingfan Xu, +8 authors Jiaoti Huang
  • Prostate Cancer and Prostatic Diseases
  • 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 71 REFERENCES

complex replication protein A

K McKinney, M Mattia, V Gottifredi, C Prives
  • J Biol Chem
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The N terminus of p53 regulates its dissociation from DNA.

  • The Journal of biological chemistry
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Core domain interactions in full-length p53 in solution.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
VIEW 1 EXCERPT

Structural basis of DNA recognition

TE Haran, Z Shakked
  • 2006

Structural basis of DNA recognition by p 53 tetramers

LJ Ko, C Prives
  • Mol Cell
  • 2006

Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 2 EXCERPTS

The complex interaction of p 53 with target DNA : we learn as we go

M Kitayner, H Rozenberg, +4 authors Z Shakked
  • Biochem Cell Biol
  • 2005