The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.

@article{Lupardus2008TheSO,
  title={The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.},
  author={Patrick J Lupardus and K Christopher Garcia},
  journal={Journal of molecular biology},
  year={2008},
  volume={382 4},
  pages={931-41}
}
Interleukin (IL)-23 is a recently identified member of the IL-12 family of heterodimeric cytokines that modulate subpopulations of T helper cells, and both IL-12 and IL-23 are attractive targets for therapy of autoimmune diseases. IL-23 is a binary complex of a four-helix bundle cytokine (p19) and a soluble class I cytokine receptor p40. IL-12 and IL-23 share p40 as an alpha-receptor subunit, yet show only 15% sequence homology between their four-helix cytokines p19 and p35, respectively, and… CONTINUE READING

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